SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS
The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes. L'invention concerne des procédés de préparation de dé...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SULEMAN, Abid HAHM, Byoungiae XIAO, Li JUNG, Dahye HWANG, Jaekwang HONG, Na KIM, Chunyoung JUNG, Jiyoung WALKER, Donald KWOK, Albert ROSA PAGAN, Kedwin PATIENCE, Daniel JUSTICE, David HWANG, Heejun COUMING, Vincent MATHIEU, Steven HUANG, Fei |
| description | The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes.
L'invention concerne des procédés de préparation de dérivés spiro, en particulier (2R,5S)-7-méthyl-2-[4-méthyl-6-[4-(trifluorométhyl)-7-méthyl-2-[4-méthyl-6-[4- (trifluorométhyl))-phényl] pyrimidin-2-yl]-1,7-diazaspiro [4,4]nonan-6-one, ainsi que des intermédiaires destinés à être utilisés dans lesdits procédés. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2022133097A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2022133097A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2022133097A13</originalsourceid><addsrcrecordid>eNqNyrEKwjAQgOEsDqK-w4FzoW0GcQzNtSmkucBdKk6lSJxEC_X90cEHcPqH79-qyNcgDrlnoBYaGiKlYBnEGYGBbPJGEBJjYTFisBgERvJiOiy6L1lgsn0aoHEmBPS8V5v7_Fjz4dedOrYojSvy8pryusy3_Mzv6UJ1WdeV1uX5ZCr93_UBWUgwNg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS</title><source>esp@cenet</source><creator>SULEMAN, Abid ; HAHM, Byoungiae ; XIAO, Li ; JUNG, Dahye ; HWANG, Jaekwang ; HONG, Na ; KIM, Chunyoung ; JUNG, Jiyoung ; WALKER, Donald ; KWOK, Albert ; ROSA PAGAN, Kedwin ; PATIENCE, Daniel ; JUSTICE, David ; HWANG, Heejun ; COUMING, Vincent ; MATHIEU, Steven ; HUANG, Fei</creator><creatorcontrib>SULEMAN, Abid ; HAHM, Byoungiae ; XIAO, Li ; JUNG, Dahye ; HWANG, Jaekwang ; HONG, Na ; KIM, Chunyoung ; JUNG, Jiyoung ; WALKER, Donald ; KWOK, Albert ; ROSA PAGAN, Kedwin ; PATIENCE, Daniel ; JUSTICE, David ; HWANG, Heejun ; COUMING, Vincent ; MATHIEU, Steven ; HUANG, Fei</creatorcontrib><description>The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes.
L'invention concerne des procédés de préparation de dérivés spiro, en particulier (2R,5S)-7-méthyl-2-[4-méthyl-6-[4-(trifluorométhyl)-7-méthyl-2-[4-méthyl-6-[4- (trifluorométhyl))-phényl] pyrimidin-2-yl]-1,7-diazaspiro [4,4]nonan-6-one, ainsi que des intermédiaires destinés à être utilisés dans lesdits procédés.</description><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220623&DB=EPODOC&CC=WO&NR=2022133097A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220623&DB=EPODOC&CC=WO&NR=2022133097A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SULEMAN, Abid</creatorcontrib><creatorcontrib>HAHM, Byoungiae</creatorcontrib><creatorcontrib>XIAO, Li</creatorcontrib><creatorcontrib>JUNG, Dahye</creatorcontrib><creatorcontrib>HWANG, Jaekwang</creatorcontrib><creatorcontrib>HONG, Na</creatorcontrib><creatorcontrib>KIM, Chunyoung</creatorcontrib><creatorcontrib>JUNG, Jiyoung</creatorcontrib><creatorcontrib>WALKER, Donald</creatorcontrib><creatorcontrib>KWOK, Albert</creatorcontrib><creatorcontrib>ROSA PAGAN, Kedwin</creatorcontrib><creatorcontrib>PATIENCE, Daniel</creatorcontrib><creatorcontrib>JUSTICE, David</creatorcontrib><creatorcontrib>HWANG, Heejun</creatorcontrib><creatorcontrib>COUMING, Vincent</creatorcontrib><creatorcontrib>MATHIEU, Steven</creatorcontrib><creatorcontrib>HUANG, Fei</creatorcontrib><title>SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS</title><description>The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes.
L'invention concerne des procédés de préparation de dérivés spiro, en particulier (2R,5S)-7-méthyl-2-[4-méthyl-6-[4-(trifluorométhyl)-7-méthyl-2-[4-méthyl-6-[4- (trifluorométhyl))-phényl] pyrimidin-2-yl]-1,7-diazaspiro [4,4]nonan-6-one, ainsi que des intermédiaires destinés à être utilisés dans lesdits procédés.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEsDqK-w4FzoW0GcQzNtSmkucBdKk6lSJxEC_X90cEHcPqH79-qyNcgDrlnoBYaGiKlYBnEGYGBbPJGEBJjYTFisBgERvJiOiy6L1lgsn0aoHEmBPS8V5v7_Fjz4dedOrYojSvy8pryusy3_Mzv6UJ1WdeV1uX5ZCr93_UBWUgwNg</recordid><startdate>20220623</startdate><enddate>20220623</enddate><creator>SULEMAN, Abid</creator><creator>HAHM, Byoungiae</creator><creator>XIAO, Li</creator><creator>JUNG, Dahye</creator><creator>HWANG, Jaekwang</creator><creator>HONG, Na</creator><creator>KIM, Chunyoung</creator><creator>JUNG, Jiyoung</creator><creator>WALKER, Donald</creator><creator>KWOK, Albert</creator><creator>ROSA PAGAN, Kedwin</creator><creator>PATIENCE, Daniel</creator><creator>JUSTICE, David</creator><creator>HWANG, Heejun</creator><creator>COUMING, Vincent</creator><creator>MATHIEU, Steven</creator><creator>HUANG, Fei</creator><scope>EVB</scope></search><sort><creationdate>20220623</creationdate><title>SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS</title><author>SULEMAN, Abid ; HAHM, Byoungiae ; XIAO, Li ; JUNG, Dahye ; HWANG, Jaekwang ; HONG, Na ; KIM, Chunyoung ; JUNG, Jiyoung ; WALKER, Donald ; KWOK, Albert ; ROSA PAGAN, Kedwin ; PATIENCE, Daniel ; JUSTICE, David ; HWANG, Heejun ; COUMING, Vincent ; MATHIEU, Steven ; HUANG, Fei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022133097A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>SULEMAN, Abid</creatorcontrib><creatorcontrib>HAHM, Byoungiae</creatorcontrib><creatorcontrib>XIAO, Li</creatorcontrib><creatorcontrib>JUNG, Dahye</creatorcontrib><creatorcontrib>HWANG, Jaekwang</creatorcontrib><creatorcontrib>HONG, Na</creatorcontrib><creatorcontrib>KIM, Chunyoung</creatorcontrib><creatorcontrib>JUNG, Jiyoung</creatorcontrib><creatorcontrib>WALKER, Donald</creatorcontrib><creatorcontrib>KWOK, Albert</creatorcontrib><creatorcontrib>ROSA PAGAN, Kedwin</creatorcontrib><creatorcontrib>PATIENCE, Daniel</creatorcontrib><creatorcontrib>JUSTICE, David</creatorcontrib><creatorcontrib>HWANG, Heejun</creatorcontrib><creatorcontrib>COUMING, Vincent</creatorcontrib><creatorcontrib>MATHIEU, Steven</creatorcontrib><creatorcontrib>HUANG, Fei</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SULEMAN, Abid</au><au>HAHM, Byoungiae</au><au>XIAO, Li</au><au>JUNG, Dahye</au><au>HWANG, Jaekwang</au><au>HONG, Na</au><au>KIM, Chunyoung</au><au>JUNG, Jiyoung</au><au>WALKER, Donald</au><au>KWOK, Albert</au><au>ROSA PAGAN, Kedwin</au><au>PATIENCE, Daniel</au><au>JUSTICE, David</au><au>HWANG, Heejun</au><au>COUMING, Vincent</au><au>MATHIEU, Steven</au><au>HUANG, Fei</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS</title><date>2022-06-23</date><risdate>2022</risdate><abstract>The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes.
L'invention concerne des procédés de préparation de dérivés spiro, en particulier (2R,5S)-7-méthyl-2-[4-méthyl-6-[4-(trifluorométhyl)-7-méthyl-2-[4-méthyl-6-[4- (trifluorométhyl))-phényl] pyrimidin-2-yl]-1,7-diazaspiro [4,4]nonan-6-one, ainsi que des intermédiaires destinés à être utilisés dans lesdits procédés.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2022133097A1 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T14%3A09%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SULEMAN,%20Abid&rft.date=2022-06-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2022133097A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |