SYNTHESIS OF COMPOUNDS THAT MODULATE USE-DEPENDENT VOLTAGE-GATED SODIUM CHANNELS

The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes. L'invention concerne des procédés de préparation de dé...

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Hauptverfasser:	SULEMAN, Abid, HAHM, Byoungiae, XIAO, Li, JUNG, Dahye, HWANG, Jaekwang, HONG, Na, KIM, Chunyoung, JUNG, Jiyoung, WALKER, Donald, KWOK, Albert, ROSA PAGAN, Kedwin, PATIENCE, Daniel, JUSTICE, David, HWANG, Heejun, COUMING, Vincent, MATHIEU, Steven, HUANG, Fei
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said processes. L'invention concerne des procédés de préparation de dérivés spiro, en particulier (2R,5S)-7-méthyl-2-[4-méthyl-6-[4-(trifluorométhyl)-7-méthyl-2-[4-méthyl-6-[4- (trifluorométhyl))-phényl] pyrimidin-2-yl]-1,7-diazaspiro [4,4]nonan-6-one, ainsi que des intermédiaires destinés à être utilisés dans lesdits procédés.