SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF

Provided in the present invention are a substituted pyridazinone compound and the use thereof. The substituted pyridazinone compound is a compound represented by general formula I, or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvate, a polymorph, a stereoisomer or an isotopic va...

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Bibliographische Detailangaben
Hauptverfasser:	LI, Huajie, WANG, Yige, SUN, Jingyong, SUN, Haoyi, YUE, Wang, WANG, Haiyang, LIU, Bo, LIU, Qingxu, LI, Yan, CHEN, Haijiao, YAO, Qingqiang, MENG, Peng, MU, Yanling, ZHANG, Feipeng, LI, Ying, WU, Zhongyu, KRENITSKY, Véronique Plantevin, WEN, Shanshan, DING, Tiandi, XIE, Weilin, ZHI, Ying
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided in the present invention are a substituted pyridazinone compound and the use thereof. The substituted pyridazinone compound is a compound represented by general formula I, or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvate, a polymorph, a stereoisomer or an isotopic variant thereof. The compound of the present invention can be used in the preparation of a drug for preventing and/or treating diseases related to thyroid hormone dysfunction. The compound has a strong THβ selectivity, good pharmacokinetic parameters and an ideal compound stability. Furthermore, the activation activity on THβ is significantly enhanced and the selectivity is improved. La présente invention concerne un composé de pyridazinone substitué et son utilisation. Le composé de pyridazinone substitué est un composé représenté par la formule I, ou un sel, promédicament, hydrate ou solvate pharmaceutiquement acceptable, un polymorphe, un stéréoisomère ou un variant isotopique de celui-ci. Le composé selon la prés