TREATMENT OF LUMINAL SUBTYPES OF HR-POSITIVE, HER2-NEGATIVE EARLY BREAST CANCER WITH PALBOCICLIB

TREATMENT OF LUMINAL SUBTYPES OF HR-POSITIVE, HER2-NEGATIVE EARLY BREAST CANCER WITH PALBOCICLIB

The invention relates to combinations, methods and uses for the treatment of ER+, PgR-, HER2-, luminal A early breast cancer, HR+, HER2-, luminal A early breast cancer with high expression of ERBB2, or HR+, HER2-, luminal B early breast cancer, using a combination therapy comprising palbociclib, or...

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Bibliographische Detailangaben
Hauptverfasser: LIU, Yuan, LECHUGA FREAN, Maria Jose, VALOTA, Olga, ZHANG, Zhe
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to combinations, methods and uses for the treatment of ER+, PgR-, HER2-, luminal A early breast cancer, HR+, HER2-, luminal A early breast cancer with high expression of ERBB2, or HR+, HER2-, luminal B early breast cancer, using a combination therapy comprising palbociclib, or a pharmaceutically acceptable salt thereof, and an endocrine therapy. L'invention concerne des combinaisons, des méthodes et des utilisations pour le traitement du cancer du sein précoce luminal A ER+, PgR-, HER2-, du cancer du sein précoce luminal A HR +, HER2- avec une expression élevée de ERBB2, ou du cancer du sein précoce luminal B HR+, HER2-, à l'aide d'une polythérapie comprenant du palbociclib, ou un sel pharmaceutiquement acceptable de celui-ci, et une thérapie endocrinienne.