TRICYCLIC KRAS G12C INHIBITORS

The present disclosure provides compounds of the formula (I) where R1, R2, R3, R4, R5, A, and B are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer. La présente invention concerne des composés de formule...

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Bibliographische Detailangaben
Hauptverfasser:	PENG, Sheng-Bin, SI, Chong, HYMAN, David Michael, LACKNER, Gregory Lawrence, RICHEY, Bree Leigh
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides compounds of the formula (I) where R1, R2, R3, R4, R5, A, and B are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer. La présente invention concerne des composés de formule (I) où R1, R2, R3, R4, R5, A et B sont tels que décrits dans la description, des sels pharmaceutiquement acceptables de ceux-ci, et des procédés d'utilisation de ces composés et de ces sels pour traiter des patients atteints d'un cancer.