BACTERIAL DELIVERY OF GENE SILENCING TOOLS INTO EUKARYOTIC CELLS

The present invention relates to a bacterial delivery system comprising a live Escherichia coli bacterium comprising at least one exogenous polynucleotide encoding an shRNA that is capable of modifying a target RNA in a eukaryotic cell after transfer into the eukaryotic cell. Also included are medic...

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Bibliographische Detailangaben
Hauptverfasser:	TAMBASCO STUDART, Marina, JOHN, Corinne, STERGIOU, Lilli, SCHAUB, Christian, BOGOS, Balazs
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a bacterial delivery system comprising a live Escherichia coli bacterium comprising at least one exogenous polynucleotide encoding an shRNA that is capable of modifying a target RNA in a eukaryotic cell after transfer into the eukaryotic cell. Also included are medical applications and in-vitro methods using the bacterial delivery system of the invention. La présente invention concerne un système d'administration bactérienne comprenant une bactérie Escherichia coli vivante comportant au moins un polynucléotide exogène codant pour un shARN qui est capable de modifier un ARN cible dans une cellule eucaryote après transfert dans la cellule eucaryote. L'invention concerne également des applications médicales et des procédés in vitro utilisant le système d'administration bactérienne de l'invention.