(AZA)BENZOTHIAZOLYL SUBSTITUTED PYRAZOLE COMPOUNDS

This application includes a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein the variables R1a, R1b, R2, R3, X, Y and Z are as defined herein, pharmaceutical compositions comprising the compounds of Formula I and methods of treatment comprising administering to a patient...

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Bibliographische Detailangaben
Hauptverfasser:	LAVERGNE, Sophie Yvette, KORCZYNSKA, Magdalena, TU, Meihua Mike, PIOTROWSKI, David Walter, FENSOME, Andrew, DOW, Robert Lee, LONDREGAN, Allyn Timothy, CABRAL, Shawn, SHAVNYA, Andre, CANTERBURY, Daniel Paul, MASCITTI, Vincent, WANG, Tao, WISNIEWSKA, Hanna Maria
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This application includes a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein the variables R1a, R1b, R2, R3, X, Y and Z are as defined herein, pharmaceutical compositions comprising the compounds of Formula I and methods of treatment comprising administering to a patient in need thereof a compound of Formula I for the treatment of transthyretin amyloidosis and diseases related thereto. La présente invention concerne un composé de formule I ou un sel pharmaceutiquement acceptable de celui-ci; les variables R1a, R1b, R2, R3, X, Y et Z étant telles que définies dans la description, des compositions pharmaceutiques comprenant les composés de formule I et des méthodes de traitement comprenant l'administration à un patient en ayant besoin d'un composé de formule I pour le traitement de l'amylose de la transthyrétine et de maladies associées à celle-ci.