AROMATIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF

Disclosed are a compound as represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor and the use thereof. The compound can be used as a protease degrading agent and/or an inhibitor, and has a good degradation and/or inhibitory effect on KRAS, especially K...

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Bibliographische Detailangaben
Hauptverfasser:	LU, Zhijian, YANG, Shuai, HUANG, Tao, FANG, Qi, YANG, Rui, XIANG, Jason Shaoyun, WANG, Suyue
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are a compound as represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor and the use thereof. The compound can be used as a protease degrading agent and/or an inhibitor, and has a good degradation and/or inhibitory effect on KRAS, especially KRAS/G12C. L'invention concerne un composé représenté par la formule I ou un sel pharmaceutiquement acceptable de celui-ci, son procédé de préparation et son utilisation. Ce composé peut être utilisé en tant qu'agent de dégradation de protéase et/ou inhibiteur et a un bon effet de dégradation et/ou d'inhibition sur KRAS, en particulier KRAS/G12C. 式I所示的化合物或其药学上可接受的盐、其制备方法及应用。所述化合物可作为蛋白酶降解剂和/或抑制剂，对KRAS尤其是KRAS G12C具有良好的降解和/或抑制作用。