FAB HIGH MANNOSE GLYCOFORMS

The present invention relates to glycosylation patterns at the Fab portion of a monoclonal antibody and methods for the regulation during culture of a microorganism expressing a monoclonal antibody with regulated content of high mannose Fab glycoforms. La présente invention concerne des motifs de gl...

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Bibliographische Detailangaben
Hauptverfasser:	JOERIS, Klaus, OEZDEN, Neslihan, HOFMANN, Carsten, LAU, Wilma, SCHMIDT, Britta, STAACK, Roland, RICHTER, Wolfgang
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to glycosylation patterns at the Fab portion of a monoclonal antibody and methods for the regulation during culture of a microorganism expressing a monoclonal antibody with regulated content of high mannose Fab glycoforms. La présente invention concerne des motifs de glycosylation au niveau de la partie Fab d'un anticorps monoclonal et des procédés pour la régulation pendant la culture d'un micro-organisme exprimant un anticorps monoclonal ayant une teneur régulée de glycoformes Fab à haute teneur en mannose.