LAPPACONITINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

A lappaconitine derivative, a preparation method therefor, and a use thereof. The derivative is an enantiomer, a diastereomer, a racemate, and a mixture thereof, as well as a pharmaceutically acceptable inorganic or organic salt, a crystal form, and a solvate thereof; six preparation methods are utilized to obtain the lappaconitine derivative, diterpenoid alkaloid structures are enriched, the lappaconitine derivative is superior to lappaconitine in combating arrhythmia and in analgesic activity, and the toxicity is less than lappaconitine, and thus a synthesized lappaconitine derivative may be used to prepare a drug for treating a cardio-cerebrovascular disease and pain. La présente invention concerne un dérivé de lappaconitine, son procédé de préparation et son utilisation. Le dérivé est un énantiomère, un diastéréoisomère, un racémate, et un mélange de ceux-ci, ainsi qu'un sel inorganique ou organique pharmaceutiquement acceptable, une forme cristalline et un solvate de celui-ci; six procédés de préparation