POLYPEPTIDE CONSTRUCTS SELECTIVELY BINDING TO CLDN6 AND CD3

The present invention relates to a polypeptide or a polypeptide construct comprising a domain which binds to Claudin 6 (CLDN6) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the construct, a vector comprising said polynucleotide and a host cell tran...

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Bibliographische Detailangaben
Hauptverfasser:	RAUM, Tobias, ANLAHR, Jonas, QUAGLIA, Silke, ALBA, Benjamin M, HONER, Jonas, BLUEMEL, Claudia, MURAWSKY, Christopher M, PHAM, Elizabeth Dang, DAHLHOFF, Christoph, GAEDTKE, Lars, BAILIS, Julie
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a polypeptide or a polypeptide construct comprising a domain which binds to Claudin 6 (CLDN6) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the construct of the invention, a medical use of said construct and a kit comprising said construct. La présente invention concerne un polypeptide ou une construction polypeptidique comprenant un domaine qui se lie à la claudine 6 (CLDN6) et un autre domaine qui se lie à CD3. De plus, l'invention concerne un polynucléotide codant pour la construction, un vecteur comprenant ledit polynucléotide et une cellule hôte transformée ou transfectée avec ledit polynucléotide ou vecteur. En outre, l'invention concerne un procédé de production de la construction de l'invention, une utilisation médicale de ladite construction et un kit comprenant ladite construction.