MASP INHIBITORY COMPOUNDS AND USES THEREOF
The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for...
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| creator | TERSTEEGEN, Adrian BIERER, Donald NEUBAUER, Thomas FLAMME, Ingo ZUBOV, Dmitry HOLTON, Simon XU, Jianchao GLATZ, Marie XIONG, Jiancheng DREHER, Jan BAUMANN, Lars JUHL, Cathleen |
| description | The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
La présente invention concerne de nouveaux composés bicycliques inhibiteurs de la sérine-protéase associée à la lectine liant le mannose (MBL) (MASP), ainsi que des procédés de préparation de ceux-ci, l'utilisation de ceux-ci seuls ou en association pour le traitement et/ou la prévention de maladies et leur utilisation pour la production de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles rénaux et cardiovasculaires et de lésions d'ischémie-reperfusion. |
| format | Patent |
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La présente invention concerne de nouveaux composés bicycliques inhibiteurs de la sérine-protéase associée à la lectine liant le mannose (MBL) (MASP), ainsi que des procédés de préparation de ceux-ci, l'utilisation de ceux-ci seuls ou en association pour le traitement et/ou la prévention de maladies et leur utilisation pour la production de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles rénaux et cardiovasculaires et de lésions d'ischémie-reperfusion.</description><language>eng ; fre</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220512&DB=EPODOC&CC=WO&NR=2022096394A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220512&DB=EPODOC&CC=WO&NR=2022096394A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TERSTEEGEN, Adrian</creatorcontrib><creatorcontrib>BIERER, Donald</creatorcontrib><creatorcontrib>NEUBAUER, Thomas</creatorcontrib><creatorcontrib>FLAMME, Ingo</creatorcontrib><creatorcontrib>ZUBOV, Dmitry</creatorcontrib><creatorcontrib>HOLTON, Simon</creatorcontrib><creatorcontrib>XU, Jianchao</creatorcontrib><creatorcontrib>GLATZ, Marie</creatorcontrib><creatorcontrib>XIONG, Jiancheng</creatorcontrib><creatorcontrib>DREHER, Jan</creatorcontrib><creatorcontrib>BAUMANN, Lars</creatorcontrib><creatorcontrib>JUHL, Cathleen</creatorcontrib><title>MASP INHIBITORY COMPOUNDS AND USES THEREOF</title><description>The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
La présente invention concerne de nouveaux composés bicycliques inhibiteurs de la sérine-protéase associée à la lectine liant le mannose (MBL) (MASP), ainsi que des procédés de préparation de ceux-ci, l'utilisation de ceux-ci seuls ou en association pour le traitement et/ou la prévention de maladies et leur utilisation pour la production de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles rénaux et cardiovasculaires et de lésions d'ischémie-reperfusion.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDydQwOUPD08_B08gzxD4pUcPb3DfAP9XMJVnD0c1EIDXYNVgjxcA1y9XfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkZGBpZmxpYmjobGxKkCAPDtJbU</recordid><startdate>20220512</startdate><enddate>20220512</enddate><creator>TERSTEEGEN, Adrian</creator><creator>BIERER, Donald</creator><creator>NEUBAUER, Thomas</creator><creator>FLAMME, Ingo</creator><creator>ZUBOV, Dmitry</creator><creator>HOLTON, Simon</creator><creator>XU, Jianchao</creator><creator>GLATZ, Marie</creator><creator>XIONG, Jiancheng</creator><creator>DREHER, Jan</creator><creator>BAUMANN, Lars</creator><creator>JUHL, Cathleen</creator><scope>EVB</scope></search><sort><creationdate>20220512</creationdate><title>MASP INHIBITORY COMPOUNDS AND USES THEREOF</title><author>TERSTEEGEN, Adrian ; BIERER, Donald ; NEUBAUER, Thomas ; FLAMME, Ingo ; ZUBOV, Dmitry ; HOLTON, Simon ; XU, Jianchao ; GLATZ, Marie ; XIONG, Jiancheng ; DREHER, Jan ; BAUMANN, Lars ; JUHL, Cathleen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022096394A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>TERSTEEGEN, Adrian</creatorcontrib><creatorcontrib>BIERER, Donald</creatorcontrib><creatorcontrib>NEUBAUER, Thomas</creatorcontrib><creatorcontrib>FLAMME, Ingo</creatorcontrib><creatorcontrib>ZUBOV, Dmitry</creatorcontrib><creatorcontrib>HOLTON, Simon</creatorcontrib><creatorcontrib>XU, Jianchao</creatorcontrib><creatorcontrib>GLATZ, Marie</creatorcontrib><creatorcontrib>XIONG, Jiancheng</creatorcontrib><creatorcontrib>DREHER, Jan</creatorcontrib><creatorcontrib>BAUMANN, Lars</creatorcontrib><creatorcontrib>JUHL, Cathleen</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TERSTEEGEN, Adrian</au><au>BIERER, Donald</au><au>NEUBAUER, Thomas</au><au>FLAMME, Ingo</au><au>ZUBOV, Dmitry</au><au>HOLTON, Simon</au><au>XU, Jianchao</au><au>GLATZ, Marie</au><au>XIONG, Jiancheng</au><au>DREHER, Jan</au><au>BAUMANN, Lars</au><au>JUHL, Cathleen</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MASP INHIBITORY COMPOUNDS AND USES THEREOF</title><date>2022-05-12</date><risdate>2022</risdate><abstract>The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
La présente invention concerne de nouveaux composés bicycliques inhibiteurs de la sérine-protéase associée à la lectine liant le mannose (MBL) (MASP), ainsi que des procédés de préparation de ceux-ci, l'utilisation de ceux-ci seuls ou en association pour le traitement et/ou la prévention de maladies et leur utilisation pour la production de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles rénaux et cardiovasculaires et de lésions d'ischémie-reperfusion.</abstract><oa>free_for_read</oa></addata></record> |
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| title | MASP INHIBITORY COMPOUNDS AND USES THEREOF |
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