MASP INHIBITORY COMPOUNDS AND USES THEREOF

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for...

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Bibliographische Detailangaben
Hauptverfasser:	TERSTEEGEN, Adrian, BIERER, Donald, NEUBAUER, Thomas, FLAMME, Ingo, ZUBOV, Dmitry, HOLTON, Simon, XU, Jianchao, GLATZ, Marie, XIONG, Jiancheng, DREHER, Jan, BAUMANN, Lars, JUHL, Cathleen
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries. La présente invention concerne de nouveaux composés bicycliques inhibiteurs de la sérine-protéase associée à la lectine liant le mannose (MBL) (MASP), ainsi que des procédés de préparation de ceux-ci, l'utilisation de ceux-ci seuls ou en association pour le traitement et/ou la prévention de maladies et leur utilisation pour la production de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles rénaux et cardiovasculaires et de lésions d'ischémie-reperfusion.