COMPOSITION COMPRISING PROTEIN EXPRESSION INHIBITOR FOR ANTIOXIDATION, ANTIINFLAMMATION, AND DEMENTIA PREVENTION OR ALLEVIATION, AND USE THEREOF

The present invention relates to a composition comprising a protein expression inhibitor for antioxidation, antiinflammation, and dementia prevention or alleviation, and a use thereof. The composition can suppress neural cell death induced by dementia-causing toxic materials in neural cells and has an excellent neuroprotective effect, thereby exhibiting preventive, alleviative, and therapeutic effects against neuronal damage, and can exhibit an excellent inhibitory effect against inflammation by effectively inhibiting inflammatory mediators induced by activated microglia, thereby preventing or treating neuroinflammation-related diseases. In addition, the composition was confirmed to have a protective action against neuronal cell death in neuronal cells and inhibit neuroinflammation in activated microglia, whereby the composition can show an effect as a pharmaceutical composition that establishes new therapeutic targets for cranial nerve diseases accompanying neuronal cell death and neuroinflammation. La présente invention concerne une composition comprenant un inhibiteur d'expression de protéine pour l'anti-oxydation, l'anti-inflammation, et la prévention ou l'atténuation de la démence, et son utilisation. La composition peut supprimer la mort des cellules neurales induite par les matériaux toxiques causant la démence dans des cellules neurales et présente un excellent effet neuroprotecteur, faisant preuve ainsi d'effets préventifs, d'atténuation, et thérapeutiques contre les lésions neuronales, et peut faire preuve d'un excellent effet inhibiteur contre l'inflammation en inhibant efficacement les médiateurs inflammatoires induits par la microglie activée, empêchant ou traitant ainsi les maladies liées à une neuro-inflammation. De plus, il a été confirmé que la composition présente une action protectrice contre la mort des cellules neuronales dans les cellules neuronales et inhibe la neuro-inflammation dans la microglie activée, moyennant quoi la composition peut présenter un effet comme composition pharmaceutique qui établit de nouvelles cibles thérapeutiques pour les maladies nerveuses crâniennes accompagnant la mort des cellules neuronales et la neuro-inflammation. 본 발명은 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매의 예방 또는 개선용 조성물 및 이의 용도에 관한 것으로, 신경세포에서 치매 유발 독성 물질에 의해 유발되는 신경세포사멸을 억제하고 우수한 신경세포 보호 효과를 가지며, 이로 인하여 신경세포 손상의 예방, 개선 및 치료 효과가 나타낼 수 있고, 활성화된 미세아교 세포에서 유도되는 염증 유발 인자를 효과적으로 저해함으로써 우수한 염증 억제 효과를 가지며, 이로 인하여 신경염증 관련 질환에 대하여 예방 또는 치료할 수 있다. 또한, 신경세포에서의 신경 세포사멸에