A DIAGNOSTIC KIT FOR USE IN THE DIAGNOSIS OF PHILADELPHIA CHROMOSOME-LIKE ACUTE LYMPHOBLASTIC LEUKEMIA

The invention is a diagnostic kit suitable for use in the diagnosis of Philadelphia-like acute lymphoblastic leukemia comprising the following genes; CD99, NOTCH1, EZH2, MPL, MLLT4, BCL2, IKZF2, FBXW7, CHD1, IRF8, IDH1, CD274, ETV6, IGJ, FLT3, CREBBP, EBF1, MLL, EPOR, JAK2, KDM6A, IRF4, IKZF3, JAK3,...

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Hauptverfasser: TEZCAN ÜNLÜ, Havva, SEZGİN EVİM, Melike, ÜNAL, Ufuk, EFENDİ ERDEM, Ecem, ÇEÇENER, Gülşah, MERAL GÜNEŞ, Adalet, BAYTAN, Birol, EGELİ, Ünal
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The invention is a diagnostic kit suitable for use in the diagnosis of Philadelphia-like acute lymphoblastic leukemia comprising the following genes; CD99, NOTCH1, EZH2, MPL, MLLT4, BCL2, IKZF2, FBXW7, CHD1, IRF8, IDH1, CD274, ETV6, IGJ, FLT3, CREBBP, EBF1, MLL, EPOR, JAK2, KDM6A, IRF4, IKZF3, JAK3, KRAS, CRLF2, HOXA9, IL7R, ABL1, LMO1, FGFR1, NF1, IFITM1, CSF1R, CA6, IDH2, CTLA4, MUC4, IKZF1, JAK1, BCL6, AICDA, KLF2, MYC, BLNK, HOXA10, BCL11B, P2RY8, SEMA6A, SOCS1, PDCD1LG2, RUNX1, PTK2B, NUDT4, PAX5, SOCS2, PICALM, NTRK3, STIL, SH2B3, TLX3, TCF3, NRAS, WT1, TP53INP1, TAL1, PDGFRA, STAT3, PBX1, SETD2, NUP214, PDCD1, PAG1, PTPN1, PDGFRB, STAT5B, ABL2, DNM2, DNTT, LYL1, NT5C2, NUP98, PTPN11, GAPDH, RAG1, RAG2, SOX11, GPR110, TLX1, G6PD, TYK2, ZCCHC7, BCR, IFITM2, BRAF, ACTB, and the algorithm analysis in which the similarity is determined. L'invention concerne un kit de diagnostic approprié pour être utilisé dans le diagnostic de la leucémie lymphoblastique aiguë du type Philadelphie comprenant les gènes suivants : CD99, NOTCH1, EZH2, MPL, MLLT4, BCL2, IKZF2, FBXW7, CHD1, IRF8, IDH1, CD274, ETV6, IGJ, FLT3, CREBBP, EBF1, MLL, EPOR, JAK2, KDM6A, IRF4, IKZF3, JAK3, KRAS, CRLF2, HOXA9, IL7R, ABL1, LMO1, FGFR1, NF1, IFITM1, CSF1R, CA6, IDH2, CTLA4, MUC4, IKZF1, JAK1, BCL6, AICDA, KLF2, MYC, BLNK, HOXA10, BCL11B, P2RY8, SEMA6A, SOCS1, PDCD1LG2, RUNX1, PTK2B, NUDT4, PAX5, SOCS2, PICALM, NTRK3, STIL, SH2B3, TLX3, TCF3, NRAS, WT1, TP53INP1, TAL1, PDGFRA, STAT3, PBX1, SETD2, NUP214, PDCD1, PAG1, PTPN1, PDGFRB, STAT5B, ABL2, DNM2, DNTT, LYL1, NT5C2, NUP98, PTPN11, GAPDH, RAG1, RAG2, SOX11, GPR110, TLX1, G6PD, TYK2, ZCCHC7, BCR, IFITM2, BRAF, ACTB et l'analyse algorithmique dans laquelle la similarité est déterminée.