MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R5, R6 have the meaning as indicated in the description and claims. The invention further rela...

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Bibliographische Detailangaben
Hauptverfasser:	ATTON, Holly Victoria, SABBAH, Mohamad
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R5, R6 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response. La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables, solvates, hydrates, tautomères ou stéréoisomères de ceux-ci, R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R5, R6 ayant la signification indiquée dans la description et les revendications. L'invention concerne en outre des compositions pharmaceutiques comprenant lesdits composés, leur utilisation en tant que médicament et dans un procédé de traitement ou de prévention d'une ou de plusieurs maladies ou troubles associés à la réponse intégrée au stress.