HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE

Provided are compounds of Formula (I) having activity as inhibitors of G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers. L'inve...

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Bibliographische Detailangaben
Hauptverfasser:	ESHON, Josephine, CHU-MOYER, Margaret, MANONI, Francesco, BANERJEE, Abhisek, KALLER, Matthew R, LANMAN, Brian Alan, LOPEZ, Patricia, ZHU, Kai, PICKRELL, Alexander J, HUANG, David, STELLWAGEN, John C, ZHANG, Wenhan, DAI, Dongcheng, LEE, Heejun, SUN, Zhen, MA, Vu Van, MEDINA, Jose M, TAMAYO, Nuria A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are compounds of Formula (I) having activity as inhibitors of G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers. L'invention concerne des composés de Formule (I) ayant une activité en tant qu'inhibiteurs de la protéine KRAS mutante G12C, des compositions pharmaceutiques comprenant les composés, ainsi que des utilisations et des méthodes de traitement de certaines affections telles que le cancer, comprenant, entre autres, le cancer du poumon, le cancer du pancréas et le cancer colorectal.