ENGINEERED GUIDE RNA FOR INCREASING EFFICIENCY OF CRISPR/CAS12F1 (CAS14A1) SYSTEM, AND USE THEREOF

The present invention relates to an engineered CRISPR/Cas12f1 (Cas14a1) system. More specifically, the present invention relates to: an engineered guide RNA for more effectively performing target nucleic acid cleavage, editing or modification; and an engineered CRISPR/Cas12f1 (Cas14a1) system compri...

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Bibliographische Detailangaben
Hauptverfasser:	MOON, Su Bin, LEE, Jeong Mi, KIM, Do Yon, KIM, Yong-Sam
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an engineered CRISPR/Cas12f1 (Cas14a1) system. More specifically, the present invention relates to: an engineered guide RNA for more effectively performing target nucleic acid cleavage, editing or modification; and an engineered CRISPR/Cas12f1 (Cas14a1) system comprising same. In addition, the present invention relates to a method for cleaving, editing or modifying a target nucleic acid by using an engineered guide RNA and an engineered CRISPR/Cas12f1 (Cas14a1) system comprising the guide RNA. La présente invention concerne un système CRISPR/Cas12f1 (Cas14a1) modifié. Plus spécifiquement, la présente invention concerne : un ARN guide modifié pour effectuer plus efficacement le clivage, l'édition ou la modification d'acide nucléique cible ; et un système CRISPR/Cas12f1 (Cas14a1) modifié le comprenant. De plus, la présente invention concerne un procédé de clivage, d'édition ou de modification d'un acide nucléique cible à l'aide d'un ARN guide modifié et d'un système CRISPR/Cas12f1 modifié (Cas14a1) comprenant l'ARN guide. 본 발명은 엔지니어링 된 CRISPR/Cas12f1(Cas14a1) 시스템에 관한 것이다. 보다 구체적으로, 본 발명은 표적 핵산의 절단, 편집 또는 변형을 더욱 효과적으로 수행하기 위한 엔지니어링 된 가이드 RNA 및 이를 포함한 엔지니어링 된 CRISPR/Cas12f1(Cas14a1) 시스템에 관한 것이다. 또한, 본 발명은 엔지니어링 된 가이드 RNA 및 이를 포함한 엔지니어링 된 CRISPR/Cas12f1(Cas14a1) 시스템를 이용한 표적 핵산의 절단, 편집 또는 변형 방법에 관한 것이다.