COMPOSITION FOR PREVENTION, ALLEVIATION OR TREATMENT OF BRAIN DAMAGE AND MILD COGNITIVE IMPAIRMENT, COMPRISING GLUTAMINE AS ACTIVE INGREDIENT

The present invention relates to a composition for prevention, alleviation, or treatment of brain damage and mild cognitive impairment, comprising glutamine or a salt thereof as an active ingredient. It was confirmed that glutamine, which is an active ingredient of the present invention, can not only restore memory and cognitive function diminished by stress, but can also inhibit nerve cell damage, reduce the content of ROS/RNS in brain tissues, as well as the expression level of proteins related thereto, and enhance synaptic plasticity, and animals with Alzheimer's disease, when fed glutamine, had enhanced cognitive ability and suppressed accumulation of Aβ42. La présente invention concerne une composition pour la prévention, le soulagement ou le traitement d'une lésion cérébrale et d'un trouble cognitif léger comprenant de la glutamine ou un sel de cette dernière en tant que principe actif. Il a été confirmé que la glutamine, qui est un principe actif de la présente invention, peut non seulement restaurer la mémoire et une fonction cognitive diminuée par le stress, mais inhiber également l'endommagement des cellules nerveuses, réduire la teneur en ROS/RNS dans les tissus cérébraux, ainsi que le niveau d'expression de protéines associées à ces derniers et améliorer la plasticité synaptique. Les animaux atteints de la maladie d'Alzheimer, lorsqu'ils ingèrent de la glutamine, présentent une meilleure capacité cognitive et une réduction de l'accumulation d'Aβ42. 본 발명은 글루타민 또는 이의 염을 유효성분으로 함유한 뇌손상 및 경도 인지장애의 예방, 개선 또는 치료용 조성물에 관한 것으로, 본 발명의 유효성분인 글루타민은 스트레스에 의해 감소한 기억력 및 인지기능을 회복시킬 뿐만 아니라, 신경세포 손상을 억제하며. 뇌조직에서 ROS/RNS의 함량을 감소시키고, 이와 관련된 단백질의 발현량도 감소시키며, 시냅스 가소성(Synaptic plasticity)을 증진시킬 수 있으며, 알츠하이머병 동물에게 글루타민을 식이한 경우, 인지능력이 증가하고, Aβ42의 축적이 억제되는 것을 확인한 것이다.