STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND HYALURONIDASE VARIANTS AND FRAGMENTS THEREOF AND METHODS OF USE THEREOF

STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND HYALURONIDASE VARIANTS AND FRAGMENTS THEREOF AND METHODS OF USE THEREOF

The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof and a PH20 variant or fragment thereof. The invention further provides methods for treating various cancers with formulations of the invention. In some embodi...

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Bibliographische Detailangaben
Hauptverfasser: MITTAL, Sachin, FORREST, William, SANGANI, Sahil, KRISHNAMACHARI, Yogita, SU, Yongchao, ZHAO, Xi
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof and a PH20 variant or fragment thereof. The invention further provides methods for treating various cancers with formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by subcutaneous administration. La présente invention concerne des formulations stables d'anticorps contre le récepteur de mort programmée PD-1 humain ou des fragments de liaison à l'antigène de ceux-ci et un variant PH20 ou un fragment de celui-ci. L'invention concerne en outre des méthodes pour traiter différents cancers au moyen des formulations selon l'invention. Dans certains modes de réalisation des méthodes de l'invention, les formulations sont administrées à un sujet par administration sous-cutanée.