A CLASS OF FUSED RING COMPOUNDS, AND PREPARATION AND USE THEREOF

The present invention belongs to the technical field of medicines, and relates to a class of fused ring compounds, and the preparation and use thereof. Test results show that the compounds can significantly inhibit the ATM kinase activity, have a good selectivity for the ATM target, and have the pha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	FAN, Lixue, LI, Chunna, ZHAO, Chuanwu, ZHANG, Yan, CHEN, Liqian, QI, Fei, WANG, Zhenyu, JIANG, Chunhua, CHAI, Xiaoling, ZHANG, Chaozai
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention belongs to the technical field of medicines, and relates to a class of fused ring compounds, and the preparation and use thereof. Test results show that the compounds can significantly inhibit the ATM kinase activity, have a good selectivity for the ATM target, and have the pharmaceutical use of treating cancer. La présente invention concerne le domaine technique des médicaments, et concerne une classe de composés cycliques fusionnés, la préparation et l'utilisation de ceux-ci. Les résultats de test montrent que les composés peuvent inhiber de manière significative l'activité de la kinase ATM, ont une sélectivité satisfaisante pour la cible ATM, et ont un usage pharmaceutique pour le traitement du cancer. 属于医药技术领域，涉及一类如式(I')所示的并环化合物及其制备和应用。试验结果表明，化合物能显著抑制ATM激酶活性，并且对ATM靶点的选择性好，具有治疗癌症的医药用途。