STAT INHIBITORY COMPOUNDS AND COMPOSITIONS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for e...

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Bibliographische Detailangaben
Hauptverfasser:	ALI, Ahmed Magdy, FLECK, Roman, ROSA, David Alexander, ALFORD, Antoine John, PROUDFOOT, John, PALERM, Angel Sampedro, DARWISH, Alla, OMEARA, Jeff, GUNNING, Patrick Thomas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer, hematological cancer, and pancreatic cancer. L'invention concerne des composés et des compositions pharmaceutiques comprenant lesdits composés qui sont utiles pour inhiber le transducteur de signal et activateur de la transcription 5a et 5b (STAT5). En outre, les composés et compositions de l'invention sont utiles pour le traitement du cancer, tel que, par exemple, le cancer du sein, le cancer hématologique et le cancer du pancréas.