DIHYDROPYRROLO[2,3-D]PYRIDAZIN-7-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

A dihydropyrrolo[2,3-d]pyridazin-7-one derivative having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, as well as a use thereof as an FGFR and mutation inhibitor, and a use thereof in the preparation of a drug for treating and/or preventin...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, Zhui, XIN, Wenqun, XU, Yaochang, YU, Hongping, DENG, Haibing
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A dihydropyrrolo[2,3-d]pyridazin-7-one derivative having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, as well as a use thereof as an FGFR and mutation inhibitor, and a use thereof in the preparation of a drug for treating and/or preventing a tumor or cancer at least partly mediated by an FGFR kinase and a tumor in a patient having resistance to an FGFR inhibitor, and especially in the preparation of a drug for treating and/or preventing a tumor in a patient having a mutation in V561, V565, N550, N540, V555, E566, K660, and/or V550 on an FGFR signaling pathway. The substituents in formula (I) have the same definitions as those in the description. L'invention concerne un dérivé de dihydropyrrolo[2,3-d]pyridazin-7-one ayant la structure de formule (I), son procédé de préparation, une composition pharmaceutique le contenant, ainsi que son utilisation en tant qu'inhibiteur de FGFR et de mutation, et une utilisation de celui-ci dans la préparation d'un m