OXOPYRROLIDINE UREA FPR2 AGONISTS

The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, ch...

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Bibliographische Detailangaben
Hauptverfasser:	MADDURI, Sudhakara Reddy, BALIGAR, Vishweshwaraiah, KICK, Ellen K, WURTZ, Nicholas R, SHIRUDE, Pravin Sudhakar, SESHADRI, Balaji, RACHAMREDDY, Chandrasekhar Reddy
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. (I) La divulgation concerne des composés de formule (I) qui sont des agonistes du récepteur 2 du peptide formyle (FPR2) et/ou des agonistes du récepteur 1 du peptide formyle (FPR1). La divulgation concerne également des compositions et des méthodes d'utilisation des composés, par exemple pour le traitement de l'athérosclérose, de l'insuffisance cardiaque, de la bronchopneumopathie chronique obstructive (BPCO) et de maladies associées. (I)