MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulato...

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Hauptverfasser: ZHOU, Jinglan, RAMTOHUL, Yeeman K, LATERREUR, Julie, REDDY, Thumkunta Jagadeeswar, HADIDA RUAH, Sara Sabina, PARASELLI, Prasuna, MILLER, Mark Thomas, CLEVELAND, Thomas, COON, Timothy R, GROOTENHUIS, Peter (Deceased), GALLANT, Michel, STURINO, Claudio, BOOKSER, Brett C, MELILLO, Vito, VALDEZ, Lino, CLEMENS, Jeremy J
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators. La présente invention concerne des modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique (CFTR), des compositions pharmaceutiques contenant au moins un tel modulateur, des procédés de traitement de la fibrose kystique à l'aide de tels modulateurs et des compositions pharmaceutiques, ainsi que des procédés de fabrication de tels modulateurs.