BTK INHIBITORS
Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutical...
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| creator | PRINCE, Robin MARX, Isaac PATTAROPONG, Vatee JONES, John LIN, Edward HOPKINS, Brian VANDEVEER, George CHEN, TeYu YOUSAF, Zain SCHULZ, Jürgen HIMMELBAUER, Martin GILFILLAN, Rab NEVALAINEN, Marta MA, Bin GONZALEZ LOPEZ DE TURISO, Felix |
| description | Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.
L'invention concerne des composés représentés par la formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m et n sont tels que définis dans la description; des compositions pharmaceutiques comprenant lesdits composés ou des sels pharmaceutiquement acceptables de ceux-ci, et des excipients pharmaceutiquement acceptables; ainsi que des méthodes de traitement d'une affection sensible à l'inhibition de la tyrosine kinase de Bruton à l'aide desdits composés, ou des sels pharmaceutiquement acceptables de ceux-ci, ou desdites compositions pharmaceutiques. |
| format | Patent |
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L'invention concerne des composés représentés par la formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m et n sont tels que définis dans la description; des compositions pharmaceutiques comprenant lesdits composés ou des sels pharmaceutiquement acceptables de ceux-ci, et des excipients pharmaceutiquement acceptables; ainsi que des méthodes de traitement d'une affection sensible à l'inhibition de la tyrosine kinase de Bruton à l'aide desdits composés, ou des sels pharmaceutiquement acceptables de ceux-ci, ou desdites compositions pharmaceutiques.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220324&DB=EPODOC&CC=WO&NR=2022032019A8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220324&DB=EPODOC&CC=WO&NR=2022032019A8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PRINCE, Robin</creatorcontrib><creatorcontrib>MARX, Isaac</creatorcontrib><creatorcontrib>PATTAROPONG, Vatee</creatorcontrib><creatorcontrib>JONES, John</creatorcontrib><creatorcontrib>LIN, Edward</creatorcontrib><creatorcontrib>HOPKINS, Brian</creatorcontrib><creatorcontrib>VANDEVEER, George</creatorcontrib><creatorcontrib>CHEN, TeYu</creatorcontrib><creatorcontrib>YOUSAF, Zain</creatorcontrib><creatorcontrib>SCHULZ, Jürgen</creatorcontrib><creatorcontrib>HIMMELBAUER, Martin</creatorcontrib><creatorcontrib>GILFILLAN, Rab</creatorcontrib><creatorcontrib>NEVALAINEN, Marta</creatorcontrib><creatorcontrib>MA, Bin</creatorcontrib><creatorcontrib>GONZALEZ LOPEZ DE TURISO, Felix</creatorcontrib><title>BTK INHIBITORS</title><description>Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.
L'invention concerne des composés représentés par la formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m et n sont tels que définis dans la description; des compositions pharmaceutiques comprenant lesdits composés ou des sels pharmaceutiquement acceptables de ceux-ci, et des excipients pharmaceutiquement acceptables; ainsi que des méthodes de traitement d'une affection sensible à l'inhibition de la tyrosine kinase de Bruton à l'aide desdits composés, ou des sels pharmaceutiquement acceptables de ceux-ci, ou desdites compositions pharmaceutiques.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOBzCvFW8PTz8HTyDPEPCuZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRkYGxkYGhpaOFsbEqQIAO8gd2Q</recordid><startdate>20220324</startdate><enddate>20220324</enddate><creator>PRINCE, Robin</creator><creator>MARX, Isaac</creator><creator>PATTAROPONG, Vatee</creator><creator>JONES, John</creator><creator>LIN, Edward</creator><creator>HOPKINS, Brian</creator><creator>VANDEVEER, George</creator><creator>CHEN, TeYu</creator><creator>YOUSAF, Zain</creator><creator>SCHULZ, Jürgen</creator><creator>HIMMELBAUER, Martin</creator><creator>GILFILLAN, Rab</creator><creator>NEVALAINEN, Marta</creator><creator>MA, Bin</creator><creator>GONZALEZ LOPEZ DE TURISO, Felix</creator><scope>EVB</scope></search><sort><creationdate>20220324</creationdate><title>BTK INHIBITORS</title><author>PRINCE, Robin ; MARX, Isaac ; PATTAROPONG, Vatee ; JONES, John ; LIN, Edward ; HOPKINS, Brian ; VANDEVEER, George ; CHEN, TeYu ; YOUSAF, Zain ; SCHULZ, Jürgen ; HIMMELBAUER, Martin ; GILFILLAN, Rab ; NEVALAINEN, Marta ; MA, Bin ; GONZALEZ LOPEZ DE TURISO, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022032019A83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PRINCE, Robin</creatorcontrib><creatorcontrib>MARX, Isaac</creatorcontrib><creatorcontrib>PATTAROPONG, Vatee</creatorcontrib><creatorcontrib>JONES, John</creatorcontrib><creatorcontrib>LIN, Edward</creatorcontrib><creatorcontrib>HOPKINS, Brian</creatorcontrib><creatorcontrib>VANDEVEER, George</creatorcontrib><creatorcontrib>CHEN, TeYu</creatorcontrib><creatorcontrib>YOUSAF, Zain</creatorcontrib><creatorcontrib>SCHULZ, Jürgen</creatorcontrib><creatorcontrib>HIMMELBAUER, Martin</creatorcontrib><creatorcontrib>GILFILLAN, Rab</creatorcontrib><creatorcontrib>NEVALAINEN, Marta</creatorcontrib><creatorcontrib>MA, Bin</creatorcontrib><creatorcontrib>GONZALEZ LOPEZ DE TURISO, Felix</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PRINCE, Robin</au><au>MARX, Isaac</au><au>PATTAROPONG, Vatee</au><au>JONES, John</au><au>LIN, Edward</au><au>HOPKINS, Brian</au><au>VANDEVEER, George</au><au>CHEN, TeYu</au><au>YOUSAF, Zain</au><au>SCHULZ, Jürgen</au><au>HIMMELBAUER, Martin</au><au>GILFILLAN, Rab</au><au>NEVALAINEN, Marta</au><au>MA, Bin</au><au>GONZALEZ LOPEZ DE TURISO, Felix</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BTK INHIBITORS</title><date>2022-03-24</date><risdate>2022</risdate><abstract>Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.
L'invention concerne des composés représentés par la formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m et n sont tels que définis dans la description; des compositions pharmaceutiques comprenant lesdits composés ou des sels pharmaceutiquement acceptables de ceux-ci, et des excipients pharmaceutiquement acceptables; ainsi que des méthodes de traitement d'une affection sensible à l'inhibition de la tyrosine kinase de Bruton à l'aide desdits composés, ou des sels pharmaceutiquement acceptables de ceux-ci, ou desdites compositions pharmaceutiques.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BTK INHIBITORS |
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