BTK INHIBITORS

Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutical...

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Bibliographische Detailangaben
Hauptverfasser:	PRINCE, Robin, MARX, Isaac, PATTAROPONG, Vatee, JONES, John, LIN, Edward, HOPKINS, Brian, VANDEVEER, George, CHEN, TeYu, YOUSAF, Zain, SCHULZ, Jürgen, HIMMELBAUER, Martin, GILFILLAN, Rab, NEVALAINEN, Marta, MA, Bin, GONZALEZ LOPEZ DE TURISO, Felix
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions. L'invention concerne des composés représentés par la formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m et n sont tels que définis dans la description; des compositions pharmaceutiques comprenant lesdits composés ou des sels pharmaceutiquement acceptables de ceux-ci, et des excipients pharmaceutiquement acceptables; ainsi que des méthodes de traitement d'une affection sensible à l'inhibition de la tyrosine kinase de Bruton à l'aide desdits composés, ou des sels pharmaceutiquement acceptables de ceux-ci, ou desdites compositions pharmaceutiques.