INOTODIOL AS AGONIST OF LIVER X RECEPTORS, AND USE THEREOF

The present invention relates to inotodiol as an agonist of liver X receptors, and a use thereof for treatment of liver X receptor-mediated diseases. Inotodiol, according to one aspect, and a prodrug thereof have agonist activity specific to LXRβ, and thus are remarkably safer than other LXRs agonis...

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Bibliographische Detailangaben
Hauptverfasser:	PARK, Hyunah, LEE, Wonhee, LEE, Chang Kyu, LEE, Nan Young, BAN, So Young, PARK, Kyubeen
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to inotodiol as an agonist of liver X receptors, and a use thereof for treatment of liver X receptor-mediated diseases. Inotodiol, according to one aspect, and a prodrug thereof have agonist activity specific to LXRβ, and thus are remarkably safer than other LXRs agonists and are effectively usable in the treatment of LXRs-related diseases, for example, degenerative brain diseases, autoimmune diseases, NASH, NAFLD, and the like. La présente invention concerne l'inotodiol en tant qu'agoniste des récepteurs X du foie, et une utilisation de celui-ci pour le traitement de maladies médiées par les récepteurs X du foie. L'inotodiol, selon un aspect, et un promédicament de celui-ci, ont une activité agoniste spécifique sur LXRβ, et sont ainsi remarquablement plus sûrs que d'autres agonistes de LXR et sont efficacement utilisables dans le traitement de maladies associées aux LXR, par exemple, des maladies cérébrales dégénératives, des maladies auto-immunes, NASH, NAFLD et similaire. 간 X 수용체 작용제로서의 이노토디올 및 이의 간 X 수용체 매개 질환의 치료 용도에 관한 것으로, 일 양상에 따른 이노토디올, 그의 전구 약물은 LXRβ에 특이적인 작용제 활성을 가짐으로써, 다른 LXRs 작용제 대비 현저한 안전성을 가질 뿐만 아니라, LXRs 관련 질환, 예를 들면, 퇴행성 뇌질환, 자가면역질환, NASH, NAFLD 등의 치료에 유용하게 사용될 수 있는 효과가 있다.