CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Provided and set forth herein are certain cyclized acetamido derivatives that are DNA Polymerase Theta (Ροlθ) inhibitors of Formula (I) and Formula (II). Also, provided are pharmaceutical compositions comprising such compounds, and methods of treating diseases treatable by inhibition of Polθ such as...

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Bibliographische Detailangaben
Hauptverfasser:	JONES, Brian Thomas, MARTINEZ, Luisruben P, BECK, Hilary Plake, DILLON, Michael Patrick
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided and set forth herein are certain cyclized acetamido derivatives that are DNA Polymerase Theta (Ροlθ) inhibitors of Formula (I) and Formula (II). Also, provided are pharmaceutical compositions comprising such compounds, and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers, using such compounds and pharmaceutical compositions. La présente invention concerne certains dérivés acétamido cyclisés qui sont des inhibiteurs d'ADN polymérase thêta (PοIθ) de formule (I) et de formule (II). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés, ainsi que des procédés de traitement de maladies pouvant être traitées par inhibition de Polθ, telles que le cancer, comprenant des cancers déficients en recombinaison homologue (RH), à l'aide de tels composés et compositions pharmaceutiques.