CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL STABILIZING IMMUNE SYNAPSE

The present invention relates to: a novel chimeric antigen receptor using a CD99 region participating in immune synapse stabilization as a backbone of the chimeric antigen receptor; immune cells comprising same; and uses thereof. Compared to CAR-T cells with the existing backbone, CD99-based CAR-T c...

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Bibliographische Detailangaben
Hauptverfasser:	CHOI, Kyungho, PARK, Hyung-Bae, CHOI, Eun-Young, YEON, Hye-Ran, NAM, Giri, LEE, Ji-Eun
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to: a novel chimeric antigen receptor using a CD99 region participating in immune synapse stabilization as a backbone of the chimeric antigen receptor; immune cells comprising same; and uses thereof. Compared to CAR-T cells with the existing backbone, CD99-based CAR-T cells form a significantly more stable immune synapse with tumor cells and show improved treatment efficiency on tumors, and thus can be advantageously used for immune cell therapy for cancer treatment. La présente invention concerne : un nouveau récepteur antigénique chimérique utilisant une région CD99 participant à la stabilisation de la synapse immunologique en tant que squelette du récepteur antigénique chimérique ; des cellules immunitaires le comprenant ; et ses utilisations. Par comparaison aux cellules CAR-T ayant le squelette existant, les cellules CAR-T basées sur CD99 forment une synapse immunitaire significativement plus stable avec des cellules tumorales et présentent une efficacité de traitement améliorée sur les tumeurs, et peuvent donc être utilisées de manière avantageuse en thérapie cellulaire immunitaire pour le traitement du cancer. 본 발명은 면역시냅스 안정화에 참여하는 CD99 부위를 키메라 항원 수용체의 백본(backbone)으로 사용하는 새로운 키메라 항원 수용체, 이를 포함하는 면역세포 및 이의 용도에 관한 것이다. CD99 기반 CAR-T 세포는 기존 backbone을 보유한 CAR-T 세포에 비해 종양 세포와 훨씬 안정적인 면역시냅스를 형성하며, 향상된 종양 치료 효율을 나타내므로, 암 치료를 위한 면역세포 치료에 유용하게 사용될 수 있다.