SOLID FORM OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
A solid form of a compound having autotaxin (ATX) inhibitory activity and represented by formula (I) or solvate thereof, wherein the solid form comprises a crystal form and/or an amorphous substance. The crystal form comprises: two non-solvate crystal forms: crystal form A and crystal form L; six hy...
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Zusammenfassung: | A solid form of a compound having autotaxin (ATX) inhibitory activity and represented by formula (I) or solvate thereof, wherein the solid form comprises a crystal form and/or an amorphous substance. The crystal form comprises: two non-solvate crystal forms: crystal form A and crystal form L; six hydrate crystal forms: crystal form B (dihydrate), crystal form D (trihydrate), crystal form G (tetrahydrate), crystal form H (monohydrate), crystal form K (dihydrate), and crystal form M-1 (monohydrate); and seven solvate crystal forms: crystal form C (hemitoluene solvate), crystal form E (monochloroform solvate), crystal form N (monodichloromethane solvate), crystal form P (monoisopropanol solvate), crystal form J-1 (hemi 2-methyltetrahydrofuran solvate), crystal form J-2 (monomethyl isobutyl ketone solvate), and crystal form M-2 (monoacetonitrile solvate). The solid form can be used in treatment and/or prevention of ATX-related diseases.
L'invention concerne une forme à l'état solide d'un composé ayant une activit |
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