BIFUNCTIONAL MOLECULES TARGETING PD-L1 AND TGF-BETA

BIFUNCTIONAL MOLECULES TARGETING PD-L1 AND TGF-BETA

Provided are anti-PD-L1 antibodies with superior activities in blocking the PD-1 and PD-L1 interactions. Also provided are multifunctional molecules that include the anti-PD-L1 antibodies or fragments thereof fused to an extracellular domain of human TGF-beta receptor type-2. L'invention concer...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GONG, Wenci, TOU, Yiwei
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Provided are anti-PD-L1 antibodies with superior activities in blocking the PD-1 and PD-L1 interactions. Also provided are multifunctional molecules that include the anti-PD-L1 antibodies or fragments thereof fused to an extracellular domain of human TGF-beta receptor type-2. L'invention concerne des anticorps anti-PD-L1 présentant des activités supérieures en termes de blocage des interactions PD-1 et PD-L1. L'invention concerne également des molécules multifonctionnelles qui comprennent les anticorps anti-PD-L1 ou des fragments de ceux-ci fusionnés à un domaine extracellulaire du récepteur de TGF-bêta humain de type 2.