SENOTHERAPEUTIC DRUGS FOR AGE-RELATED DISEASES AND CANCER

The present invention relates to senotherapeutic drags targeting cellular senescence for age-related diseases such as intervertebral disc degeneration and cancer. More particularly, there is disclosed a pharmaceutical composition comprising a purified and optionally an antagonist of toll-like recept...

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Bibliographische Detailangaben
Hauptverfasser:	MANNARINO, Matthew, HAGLUND, Lisbet Agneta, CHERIF, Hosni
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to senotherapeutic drags targeting cellular senescence for age-related diseases such as intervertebral disc degeneration and cancer. More particularly, there is disclosed a pharmaceutical composition comprising a purified and optionally an antagonist of toll-like receptor 2 or 4, e.g., RG-7112. La présente invention concerne des médicaments sénothérapeutiques ciblant la sénescence cellulaire pour des maladies liées à l'âge telles que la dégénérescence du disque intervertébral et le cancer. Plus particulièrement, une composition pharmaceutique comprenant un antagoniste du récepteur de type Toll 2 ou 4, par exemple, RG -7112 est divulguée.