IN SITU THIOL-MALEIMIDE CROSSLINKED HYDROGEL FOR IMMUNE CHECKPOINT BLOCKADE DELIVERY

Disclosed are hydrogel compositions that can be used to deliver therapeutic agents, including therapeutic proteins, to patients in need thereof. In an embodiment, the therapeutic agent is an immune checkpoint blockade antibody, and the hydrogel is a thermoresponsive polymer crosslinked with a hydrop...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Jihoon, THOMAS, Susan Napier
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	Disclosed are hydrogel compositions that can be used to deliver therapeutic agents, including therapeutic proteins, to patients in need thereof. In an embodiment, the therapeutic agent is an immune checkpoint blockade antibody, and the hydrogel is a thermoresponsive polymer crosslinked with a hydrophilic polymer. L'invention concerne des compositions d'hydrogel qui peuvent être utilisées pour administrer des agents thérapeutiques, comprenant des protéines thérapeutiques, à des patients en ayant besoin. Dans un mode de réalisation, l'agent thérapeutique est un anticorps de blocage de point de contrôle immunitaire, et l'hydrogel est un polymère thermosensible réticulé par un polymère hydrophile.