ATOMIC LAYER DEPOSITION COATED PHARMACEUTICAL PACKAGING AND IMPROVED SYRINGES AND VIALS, E.G. FOR LYOPHILIZED/COLD-CHAIN DRUGS/VACCINES

The present disclosure is directed to pharmaceutical packaging such as syringes, vials, and blood tubes having a thermoplastic wall that is coated with a gas barrier coating in which at least one layer is applied by atomic layer deposition. The gas barrier coating may include, for example, one or mo...

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Hauptverfasser: ABRAMS, Robert S, TAHA, Ahmad, FERRER, Javier, BREELAND, Adam
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creator ABRAMS, Robert S
TAHA, Ahmad
FERRER, Javier
BREELAND, Adam
description The present disclosure is directed to pharmaceutical packaging such as syringes, vials, and blood tubes having a thermoplastic wall that is coated with a gas barrier coating in which at least one layer is applied by atomic layer deposition. The gas barrier coating may include, for example, one or more layers of SiO2, one or more layers of Al2O3, or a combination thereof, and may serve as a barrier against a variety of gases including oxygen, water vapor, and nitrogen. The present disclosure is also directed to syringes and vials which are configured for the storage of lyophilized or cold-chain drugs and in particular to maintain container closure integrity throughout the supply and storage conditions associated with such drugs. The present disclosure is also directed to evacuated blood tubes having extended shelf lives. La présente invention concerne un emballage pharmaceutique tel que des seringues, des flacons, et des tubes de sang ayant une paroi thermoplastique qui est revêtue d'un revêtement de barrière contre les gaz dans lequel au moins une couche est appliquée par dépôt de couche atomique. Le revêtement de barrière contre les gaz peut comprendre, par exemple, une ou plusieurs couches de SiO2, une ou plusieurs couches d'Al2O3, ou une combinaison de celles-ci, et peut servir de barrière contre une variété de gaz comprenant de l'oxygène, de la vapeur d'eau et de l'azote. La présente invention concerne également des seringues et des flacons qui sont conçus pour le stockage de médicaments lyophilisés ou soumis à la chaîne du froid et en particulier pour maintenir l'intégrité de la fermeture de récipient tout au long des conditions de fourniture et de stockage associées à de tels médicaments. La présente invention concerne également des tubes de sang sous vide ayant des durées de conservation prolongées.
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The present disclosure is also directed to syringes and vials which are configured for the storage of lyophilized or cold-chain drugs and in particular to maintain container closure integrity throughout the supply and storage conditions associated with such drugs. The present disclosure is also directed to evacuated blood tubes having extended shelf lives. La présente invention concerne un emballage pharmaceutique tel que des seringues, des flacons, et des tubes de sang ayant une paroi thermoplastique qui est revêtue d'un revêtement de barrière contre les gaz dans lequel au moins une couche est appliquée par dépôt de couche atomique. Le revêtement de barrière contre les gaz peut comprendre, par exemple, une ou plusieurs couches de SiO2, une ou plusieurs couches d'Al2O3, ou une combinaison de celles-ci, et peut servir de barrière contre une variété de gaz comprenant de l'oxygène, de la vapeur d'eau et de l'azote. La présente invention concerne également des seringues et des flacons qui sont conçus pour le stockage de médicaments lyophilisés ou soumis à la chaîne du froid et en particulier pour maintenir l'intégrité de la fermeture de récipient tout au long des conditions de fourniture et de stockage associées à de tels médicaments. 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FOR LYOPHILIZED/COLD-CHAIN DRUGS/VACCINES</title><date>2022-03-10</date><risdate>2022</risdate><abstract>The present disclosure is directed to pharmaceutical packaging such as syringes, vials, and blood tubes having a thermoplastic wall that is coated with a gas barrier coating in which at least one layer is applied by atomic layer deposition. The gas barrier coating may include, for example, one or more layers of SiO2, one or more layers of Al2O3, or a combination thereof, and may serve as a barrier against a variety of gases including oxygen, water vapor, and nitrogen. The present disclosure is also directed to syringes and vials which are configured for the storage of lyophilized or cold-chain drugs and in particular to maintain container closure integrity throughout the supply and storage conditions associated with such drugs. The present disclosure is also directed to evacuated blood tubes having extended shelf lives. La présente invention concerne un emballage pharmaceutique tel que des seringues, des flacons, et des tubes de sang ayant une paroi thermoplastique qui est revêtue d'un revêtement de barrière contre les gaz dans lequel au moins une couche est appliquée par dépôt de couche atomique. Le revêtement de barrière contre les gaz peut comprendre, par exemple, une ou plusieurs couches de SiO2, une ou plusieurs couches d'Al2O3, ou une combinaison de celles-ci, et peut servir de barrière contre une variété de gaz comprenant de l'oxygène, de la vapeur d'eau et de l'azote. La présente invention concerne également des seringues et des flacons qui sont conçus pour le stockage de médicaments lyophilisés ou soumis à la chaîne du froid et en particulier pour maintenir l'intégrité de la fermeture de récipient tout au long des conditions de fourniture et de stockage associées à de tels médicaments. La présente invention concerne également des tubes de sang sous vide ayant des durées de conservation prolongées.</abstract><oa>free_for_read</oa></addata></record>
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subjects BABY COMFORTERS
CHEMICAL SURFACE TREATMENT
CHEMISTRY
COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATIONOR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY IONIMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
COATING MATERIAL WITH METALLIC MATERIAL
COATING METALLIC MATERIAL
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES
DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR RECEIVING SPITTLE
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS
DIFFUSION TREATMENT OF METALLIC MATERIAL
HUMAN NECESSITIES
HYGIENE
INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION INGENERAL
MEDICAL OR VETERINARY SCIENCE
METALLURGY
SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THESURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION
title ATOMIC LAYER DEPOSITION COATED PHARMACEUTICAL PACKAGING AND IMPROVED SYRINGES AND VIALS, E.G. FOR LYOPHILIZED/COLD-CHAIN DRUGS/VACCINES
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