ATOMIC LAYER DEPOSITION COATED PHARMACEUTICAL PACKAGING AND IMPROVED SYRINGES AND VIALS, E.G. FOR LYOPHILIZED/COLD-CHAIN DRUGS/VACCINES

The present disclosure is directed to pharmaceutical packaging such as syringes, vials, and blood tubes having a thermoplastic wall that is coated with a gas barrier coating in which at least one layer is applied by atomic layer deposition. The gas barrier coating may include, for example, one or mo...

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Bibliographische Detailangaben
Hauptverfasser:	ABRAMS, Robert S, TAHA, Ahmad, FERRER, Javier, BREELAND, Adam
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BABY COMFORTERS CHEMICAL SURFACE TREATMENT CHEMISTRY COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATIONOR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY IONIMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL COATING MATERIAL WITH METALLIC MATERIAL COATING METALLIC MATERIAL CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR RECEIVING SPITTLE DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS DIFFUSION TREATMENT OF METALLIC MATERIAL HUMAN NECESSITIES HYGIENE INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION INGENERAL MEDICAL OR VETERINARY SCIENCE METALLURGY SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THESURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION
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Beschreibung
Zusammenfassung:	The present disclosure is directed to pharmaceutical packaging such as syringes, vials, and blood tubes having a thermoplastic wall that is coated with a gas barrier coating in which at least one layer is applied by atomic layer deposition. The gas barrier coating may include, for example, one or more layers of SiO2, one or more layers of Al2O3, or a combination thereof, and may serve as a barrier against a variety of gases including oxygen, water vapor, and nitrogen. The present disclosure is also directed to syringes and vials which are configured for the storage of lyophilized or cold-chain drugs and in particular to maintain container closure integrity throughout the supply and storage conditions associated with such drugs. The present disclosure is also directed to evacuated blood tubes having extended shelf lives. La présente invention concerne un emballage pharmaceutique tel que des seringues, des flacons, et des tubes de sang ayant une paroi thermoplastique qui est revêtue d'un revêtement de barrière contre les gaz dans lequel au moins une couche est appliquée par dépôt de couche atomique. Le revêtement de barrière contre les gaz peut comprendre, par exemple, une ou plusieurs couches de SiO2, une ou plusieurs couches d'Al2O3, ou une combinaison de celles-ci, et peut servir de barrière contre une variété de gaz comprenant de l'oxygène, de la vapeur d'eau et de l'azote. La présente invention concerne également des seringues et des flacons qui sont conçus pour le stockage de médicaments lyophilisés ou soumis à la chaîne du froid et en particulier pour maintenir l'intégrité de la fermeture de récipient tout au long des conditions de fourniture et de stockage associées à de tels médicaments. La présente invention concerne également des tubes de sang sous vide ayant des durées de conservation prolongées.