CONDITIONALLY ACTIVE ANTI-NECTIN-4 ANTIBODIES

CONDITIONALLY ACTIVE ANTI-NECTIN-4 ANTIBODIES

Isolated polypeptides having a heavy chain variable region and/or light chain variable region that specifically binds to Nectin-4 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to Nectin-4 protein. Phar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHORT, Jay M, XING, Chao, CUGNETTI, Ana Paula, WANG, Jing, LIU, Haizhen, CHANG, Hwai Wen, FREY, Gerhard
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Beschreibung
Zusammenfassung:Isolated polypeptides having a heavy chain variable region and/or light chain variable region that specifically binds to Nectin-4 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to Nectin-4 protein. Pharmaceutical compositions and kits comprising the polypeptide and antibodies and antibody fragments containing the polypeptide are also provided. L'invention concerne des polypeptides isolés ayant une région variable de chaîne lourde et/ou une région variable de chaîne légère qui se lient de manière spécifique à la protéine Nectine-4, ainsi que des anticorps et des fragments d'anticorps contenant la région variable de chaîne lourde et/ou la région variable de chaîne légère qui se lient à la protéine Nectine-4. L'invention concerne également des compositions pharmaceutiques et des kits comprenant le polypeptide, les anticorps et les fragments d'anticorps contenant le polypeptide.