SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF

Described herein are compounds of Formula I and their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for...

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Hauptverfasser:	SAMMONS, Matthew Forrest, GARNSEY, Michelle Renee, POLIVKOVA, Jana, YANG, Qingyi, BUTLER, Christopher Ryan, OGILVIE, Kevin Alexander, SMITH, Aaron Christopher
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are compounds of Formula I and their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts. L'invention concerne des composés représentés par la formule I : et leurs sels pharmaceutiquement acceptables, formule dans laquelle R1, R2, R3, X1, Y1, Y2, Y3, Y4 et Y5 sont tels que définis dans la description ; leur utilisation en tant qu'antagonistes de MC4R ; des compositions pharmaceutiques contenant de tels composés et sels ; l'utilisation de tels composés et sels pour traiter, par exemple, la cachexie, l'anorexie, ou l'anorexie mentale ; ainsi que des intermédiaires et des procédés de préparation de tels composés et sels.