ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF
The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells,...
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| creator | CULYBA, Elizabeth NGUYEN, Phuong SAZINSKY, Stephen NOVOBRANTSEVA, Tatiana RAZLOG, Maja FELDMAN, Igor |
| description | The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
La présente invention est basée, en partie, sur la découverte d'une composition anti-VSIG4 (par exemple, des anticorps monoclonaux et leurs fragments de liaison à l'antigène), qui régulent les phénotypes inflammatoires des cellules myéloïdes, tels que les cellules myéloïdes suppressives, les monocytes, les macrophages, les neutrophiles et/ou les cellules dendritiques, comprenant la polarisation, l'activation et/ou la fonction, et des procédés d'utilisation de ces compositions anti-VSIG4 à des fins thérapeutiques, diagnostiques, pronostiques et de criblage. |
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La présente invention est basée, en partie, sur la découverte d'une composition anti-VSIG4 (par exemple, des anticorps monoclonaux et leurs fragments de liaison à l'antigène), qui régulent les phénotypes inflammatoires des cellules myéloïdes, tels que les cellules myéloïdes suppressives, les monocytes, les macrophages, les neutrophiles et/ou les cellules dendritiques, comprenant la polarisation, l'activation et/ou la fonction, et des procédés d'utilisation de ces compositions anti-VSIG4 à des fins thérapeutiques, diagnostiques, pronostiques et de criblage.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211202&DB=EPODOC&CC=WO&NR=2021243169A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211202&DB=EPODOC&CC=WO&NR=2021243169A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CULYBA, Elizabeth</creatorcontrib><creatorcontrib>NGUYEN, Phuong</creatorcontrib><creatorcontrib>SAZINSKY, Stephen</creatorcontrib><creatorcontrib>NOVOBRANTSEVA, Tatiana</creatorcontrib><creatorcontrib>RAZLOG, Maja</creatorcontrib><creatorcontrib>FELDMAN, Igor</creatorcontrib><title>ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF</title><description>The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
La présente invention est basée, en partie, sur la découverte d'une composition anti-VSIG4 (par exemple, des anticorps monoclonaux et leurs fragments de liaison à l'antigène), qui régulent les phénotypes inflammatoires des cellules myéloïdes, tels que les cellules myéloïdes suppressives, les monocytes, les macrophages, les neutrophiles et/ou les cellules dendritiques, comprenant la polarisation, l'activation et/ou la fonction, et des procédés d'utilisation de ces compositions anti-VSIG4 à des fins thérapeutiques, diagnostiques, pronostiques et de criblage.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi8sKwjAQAHvxIOo_LHgu2AdCj6HZNIEkW5qt0lMpEvEgWqj_j4J-gKeZw8w6uQnPJj0F05RQk2spGDbkAwgvwSFrkgEUdeBI9law8Q24AS0ZCTVaC8YrK5wTTN0ArUZPPLT4_fvwEdbYIaltsrpO9yXuftwke4Vc6zTOzzEu83SJj_gaz5Qf8iwvi-xYiaz4r3oDJx823w</recordid><startdate>20211202</startdate><enddate>20211202</enddate><creator>CULYBA, Elizabeth</creator><creator>NGUYEN, Phuong</creator><creator>SAZINSKY, Stephen</creator><creator>NOVOBRANTSEVA, Tatiana</creator><creator>RAZLOG, Maja</creator><creator>FELDMAN, Igor</creator><scope>EVB</scope></search><sort><creationdate>20211202</creationdate><title>ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF</title><author>CULYBA, Elizabeth ; NGUYEN, Phuong ; SAZINSKY, Stephen ; NOVOBRANTSEVA, Tatiana ; RAZLOG, Maja ; FELDMAN, Igor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021243169A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CULYBA, Elizabeth</creatorcontrib><creatorcontrib>NGUYEN, Phuong</creatorcontrib><creatorcontrib>SAZINSKY, Stephen</creatorcontrib><creatorcontrib>NOVOBRANTSEVA, Tatiana</creatorcontrib><creatorcontrib>RAZLOG, Maja</creatorcontrib><creatorcontrib>FELDMAN, Igor</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CULYBA, Elizabeth</au><au>NGUYEN, Phuong</au><au>SAZINSKY, Stephen</au><au>NOVOBRANTSEVA, Tatiana</au><au>RAZLOG, Maja</au><au>FELDMAN, Igor</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF</title><date>2021-12-02</date><risdate>2021</risdate><abstract>The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF |
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