ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF

The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells,...

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Bibliographische Detailangaben
Hauptverfasser:	CULYBA, Elizabeth, NGUYEN, Phuong, SAZINSKY, Stephen, NOVOBRANTSEVA, Tatiana, RAZLOG, Maja, FELDMAN, Igor
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes. La présente invention est basée, en partie, sur la découverte d'une composition anti-VSIG4 (par exemple, des anticorps monoclonaux et leurs fragments de liaison à l'antigène), qui régulent les phénotypes inflammatoires des cellules myéloïdes, tels que les cellules myéloïdes suppressives, les monocytes, les macrophages, les neutrophiles et/ou les cellules dendritiques, comprenant la polarisation, l'activation et/ou la fonction, et des procédés d'utilisation de ces compositions anti-VSIG4 à des fins thérapeutiques, diagnostiques, pronostiques et de criblage.