CURCUMIN DIHYDROPYRIDONE DERIVATIVES WITH ANTI-CANCER ACTIVITY

The present invention includes DHPDO curcumin derivatives (6) having the following general structure: These DHPDO curcumin derivatives have pronounced anti-cancer activity with lower toxicity on normal cells. Specifically, these compounds can be used in the treatment of breast cancer and colorectal...

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1. Verfasser:	SMITS, Rufus
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention includes DHPDO curcumin derivatives (6) having the following general structure: These DHPDO curcumin derivatives have pronounced anti-cancer activity with lower toxicity on normal cells. Specifically, these compounds can be used in the treatment of breast cancer and colorectal cancer. La présente invention concerne des dérivés de curcumine DHPDO (6) ayant la structure générale suivante : 6 Ces dérivés de curcumine DHPDO présentent une activité anticancéreuse prononcée avec une faible toxicité sur des cellules normales. En particulier, ces composés peuvent être utilisés dans le traitement du cancer du sein et du cancer colorectal.