OLIGONUCLEOTIDES FOR SPLICE MODULATION OF CARD9

The present invention relates to splice modulating oligonucleotides (oligomers) that are complementary to the CARD9 pre-mRNA, for inhibiting the inclusion of a CARD9 exon 11 in CARD9 mRNA. The oligonucleotides of the invention are useful in the treatment of inflammatory diseases such as IBD. La prés...

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Bibliographische Detailangaben
Hauptverfasser:	SAI, Kristina Mary, HOEG, Anja Moelhart, BYRNE, Fergus, FINE, Jay, WAHLE, Joe Adam, KLEIN, Elliott Sanford, MBOW, Mouhamadou, SHEN, Fei, JOENSON, Lars, HAGEDORN, Peter, VIKESSA, Jonas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to splice modulating oligonucleotides (oligomers) that are complementary to the CARD9 pre-mRNA, for inhibiting the inclusion of a CARD9 exon 11 in CARD9 mRNA. The oligonucleotides of the invention are useful in the treatment of inflammatory diseases such as IBD. La présente invention concerne des oligonucléotides de modulation d'épissage (oligomères) qui sont complémentaires du pré-ARNm de CARD9, pour inhiber l'inclusion d'un exon 11 de CARD9 dans l'ARNm de CARD9. Les oligonucléotides de l'invention sont utiles dans le traitement de maladies inflammatoires telles que l'IBD.