COMPOSITIONS OF PROTEIN COMPLEXES AND METHODS OF USE THEREOF

COMPOSITIONS OF PROTEIN COMPLEXES AND METHODS OF USE THEREOF

Provided herein are protein complexes comprising a sensor domain and a therapeutic domain linked by a linker, and methods of use thereof. In aspects of the present disclosure, activity of the therapeutic domain comprises a dependence on sensor domain binding to target markers. L'invention conce...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MULLIGAN, John Thomas, HOLLENBAUGH, Diane Louise, OKADA, Shannon Lee, KILLEBREW, Justin Richard
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are protein complexes comprising a sensor domain and a therapeutic domain linked by a linker, and methods of use thereof. In aspects of the present disclosure, activity of the therapeutic domain comprises a dependence on sensor domain binding to target markers. L'invention concerne des complexes protéiques comprenant un domaine de sonde et un domaine thérapeutique liés par un lieur, et leurs méthodes d'utilisation. Selon des aspects de la présente divulgation, l'activité du domaine thérapeutique comprend un domaine dépendant de la sonde se liant à des marqueurs cibles.