COMPLEMENT COMPONENT C1R INHIBITORS FOR TREATING A NEUROLOGICAL DISEASE, AND RELATED COMPOSITIONS, SYSTEMS AND METHODS OF USING SAME

The present invention relates to complement C1r subcomponent (C1R) inhibitors for use in treatment of neurological diseases. The invention in particular relates to the use of C1R inhibitors for down-regulation of C1R expression. The invention also relates to nucleic acid molecules, which are complem...

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Hauptverfasser:	GYLLING, Helene M, HANSON, Jesse Eric, MUNK, Alexander, KIELPINSKI, Lukasz J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to complement C1r subcomponent (C1R) inhibitors for use in treatment of neurological diseases. The invention in particular relates to the use of C1R inhibitors for down-regulation of C1R expression. The invention also relates to nucleic acid molecules, which are complementary to C1R and capable of reducing the level of an C1R mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of neurological diseases. La présente invention concerne des inhibiteurs du sous-composant C1r du complément (C1R) destinés à être utilisés dans le traitement de maladies neurologiques. L'invention concerne en particulier l'utilisation d'inhibiteurs de C1R pour la régulation négative de l'expression de C1R. L'invention concerne également des molécules d'acide nucléique, qui sont complémentaires du C1R et capables de réduire le niveau d'un ARNm C1R. La présente invention concerne en outre une composition pharmaceutique et son utilisation dans le traitement des maladies neurologiques.