COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASE CONTAINING AMPHIREGULIN-SPECIFIC DOUBLE-STRANDED OLIGONUCLEOTIDE STRUCTURE

The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit amphiregulin expression, preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; and a use, of a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, for preventing or treating obesity. La présente invention concerne : un oligonucléotide bicaténaire qui peut inhiber de manière hautement spécifique et efficace l'expression de l'amphiréguline et, de préférence, un oligonucléotide bicaténaire comprenant une séquence sous la forme ARN/ARN, ADN/ADN ou hybride ADN/ARN; et une utilisation d'une structure oligonucléotidique bicaténaire et de nanoparticules comprenant l'oligonucléotide bicaténaire dans la prévention ou le traitement de l'obésité. 본 발명은 엠피레귤린 발현을 매우 특이적이고 높은 효율로 저해할 수 있는 이중가닥 올리고뉴클레오티드, 바람직하게는 RNA/RNA, DNA/DNA, 또는 DNA/RNA hybrid 형태의 서열을 포함하는 이중가닥 올리고뉴클레오티드, 상기 이중가닥 올리고뉴클레오티드를 포함하는 이중가닥 올리고뉴클레오티드 구조체 및 나노입자의 비만의 예방 또는 치료 용도에 관한 것이다.