OLIGONUCLEOTIDE AGONISTS TARGETING PROGRANULIN

The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency. La présente invention concerne des oligonucléotides qui régul...

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Bibliographische Detailangaben
Hauptverfasser:	JAGASIA, Ravi, JOENSON, Lars, TEHLER, Disa, WORM, Jesper, LARSEN, Dorthe Vang, RASMUSSEN, Søren
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency. La présente invention concerne des oligonucléotides qui régulent vers le haut ou rétablissent l'expression de la progranuline dans des cellules, et leur utilisation dans le traitement de troubles neurologiques, et de troubles associés à l'haploinsuffisance de la progranuline.