NANO ANTIBODY AND USE THEREOF

Provided is a nano antibody, the amino acid sequence thereof being EVQLQASGGGFVQPGGSLRLSCAASGFTFSSX1AMGWFRQAPGKEREX2VSAISSGGGNTYYADSVKGRFTISRDNSKNTVYLQMNSLRAEDTATYYCVTPGGRLWYYRYDYRCQGTQVTVSS (SEQ ID NO:1), wherein X1 is selected from Y or F, and X2 is selected from F or L. The antibody can be used t...

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Bibliographische Detailangaben
Hauptverfasser:	QIN, Yaobin, YANG, Jianfeng, SONG, Zhe, ZHANG, Lei, LI, Xianggan, DONG, Qiuping, ZHU, Zhiwei, LI, Yuejin, QI, Youlin, HOU, Limin, WANG, Jinyu
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	Provided is a nano antibody, the amino acid sequence thereof being EVQLQASGGGFVQPGGSLRLSCAASGFTFSSX1AMGWFRQAPGKEREX2VSAISSGGGNTYYADSVKGRFTISRDNSKNTVYLQMNSLRAEDTATYYCVTPGGRLWYYRYDYRCQGTQVTVSS (SEQ ID NO:1), wherein X1 is selected from Y or F, and X2 is selected from F or L. The antibody can be used to dissolve Charcot-Leyden crystals (CLCs), thereby reducing pulmonary inflammation, changes in lung function, and mucus production. Further provided is the use of the nano antibody in the preparation of a drug and a reagent for detecting Charcot-Leyden crystals (CLCs) and/or Galectin-10 protein. L'invention concerne un nanoanticorps dont la séquence d'acides aminés est EVQLQASGGGFVQPGGSLRLSCAASGFTFSSX1AMGWFRQAPGKEREX2VSAISSGGGNTYYADSVKGRFTISRDNSKNTVYLQMNSLRAEDTATYYCVTPGGRLWYYRYDYRCQGTQVTVSS (SEQ ID NO : 1), dans laquelle X1 est choisi parmi Y ou F, et X2 est choisi parmi F ou L. L'anticorps peut être utilisé pour dissoudre des cristaux de Charcot-Leyden (CLC), ce qui permet de réduire l'inflammation pulmonaire, les