MULTIMERIC OLIGONUCLEOTIDES WITH DIVIDED STRANDS

The present disclosure relates to multimeric oligonucleotides comprising subunits, each of the subunits independently comprises a single-stranded or double-stranded oligonucleotide. Each of the subunits is joined to another subunit by a covalent linker, and at least one subunit comprises at least on...

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Bibliographische Detailangaben
1. Verfasser:	BROWN, Jonathan Miles
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to multimeric oligonucleotides comprising subunits, each of the subunits independently comprises a single-stranded or double-stranded oligonucleotide. Each of the subunits is joined to another subunit by a covalent linker, and at least one subunit comprises at least one partial single-stranded oligonucleotide. The present disclosure also relates to methods of synthesizing the multimeric oligonucleotides and the methods of using the multimeric oligonucleotides disclosed herein. La présente invention concerne des oligonucléotides multimères comprenant des sous-unités, chacune des sous-unités comprenant indépendamment un oligonucléotide monocaténaire ou bicaténaire. Chacune des sous-unités est jointe à une autre sous-unité par un lieur covalent, et au moins une sous-unité comprend au moins un oligonucléotide monocaténaire partiel. La présente invention concerne également des procédés de préparation et des procédés d'utilisation des oligonucléotides multimères de l'invention.