ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF

Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRα) antigen- binding domain, wherein the 4-1BB-binding domain and the FRα antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modif...

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Bibliographische Detailangaben
Hauptverfasser:	WICKMAN, Grant Raymond, CHAN, Peter Wing Yiu, VOLKERS, Gesa, HALVORSEN, Elizabeth, VON ROSSUM, Anna, FREIBURGER, Lee, KANG, Sukhbir Singh, CLAVETTE, Brandon, PRATAP, Harsh, UROSEV, Dunja, SPRETER VON KREUDENSTEIN, Thomas, JANCOWSKI, Sylwia, CHUI, Danny, PATTON, Daniel T, MILLS, David M, DUAN, Zhuang, ZWIERZCHOWSKI, Patricia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRα) antigen- binding domain, wherein the 4-1BB-binding domain and the FRα antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer. L'invention concerne des constructions d'anticorps comprenant un domaine de liaison à 4-1BB et un domaine de liaison à l'antigène anti-récepteur α de folate (FRα), le domaine de liaison à 4-1BB et le domaine de liaison à l'antigène FRα étant liés directement ou indirectement à un échafaudage. L'échafaudage peut être une construction Fc avec des modifications qui réduisent sa capacité à médier la fonction effectrice. Les constructions d'anticorps sont utilisées dans le traitement d'un sujet atteint d'un cancer.