ANTIGEN-BINDING POLYPEPTIDE BINDING TO CD47, AND USE THEREOF

Provided are an antigen-binding polypeptide binding to CD47 or an antigen-binding portion thereof, and a nucleic acid, vector, cell or pharmaceutical composition encoding the polypeptide. The polypeptide can reduce a tumor or inhibit the growth of tumor cells, treat cancer, promote macrophage phagoc...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Xiaoyun, GUI, Qiu, ZOU, Xiaofang, SHEN, Hengqiao, ZHU, Hong, XU, Hongjiang, WANG, Liangliang, YANG, Ling
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are an antigen-binding polypeptide binding to CD47 or an antigen-binding portion thereof, and a nucleic acid, vector, cell or pharmaceutical composition encoding the polypeptide. The polypeptide can reduce a tumor or inhibit the growth of tumor cells, treat cancer, promote macrophage phagocytosis, and the like. L'invention concerne un polypeptide de liaison à l'antigène se liant à CD47 ou une partie de liaison à l'antigène de celui-ci, et un acide nucléique, un vecteur, une cellule ou une composition pharmaceutique codant pour le polypeptide. Le polypeptide peut réduire une tumeur ou inhiber la croissance de cellules tumorales, traiter le cancer, favoriser la phagocytose des macrophages, etc.. 提供一种结合CD47的抗原结合多肽或其抗原结合部分，以及编码多肽的核酸、载体、细胞、药物组合物，该多肽可减少肿瘤或抑制肿瘤细胞生长、治疗癌症、促进巨噬细胞吞噬作用等。